Signalling mechanisms of neurite outgrowth
20 years ago we discovered the nerve fiber growth inhibiting protein Nogo-A. We described that Nogo-A is mainly present in the myelin sheath surrounding axons and we developed functionally blocking antibodies against Nogo-A to confirm its inhibitory role in cell culture experiments and in vivo.
The Nogo receptor complex and Nogo induced intracellular signaling
Nogo-A induces a rapid collapse of the actin cytoskeleton of growth cones mediated by different proteins. Experiments to explore the intracellular signaling of Nogo-A, the internalization by endocytosis of soluble Nogo fragments and Nogo receptor complexes are underway.