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Institute for Regenerative Medicine • IREM

Clinical Trials

Clinical trial with anti-Nogo antibodies

In collaboration with the European clinical research team NISCI (, we conducted a clinical trial with human anti-human antibodies against Nogo-A in acutely injured tetraplegic patients. Anti-Nogo-A antibody was proven to be safe, well tolerable and feasible, and the pharmacokinetics showed no abnormalities (Kucher et al., 2018). Based on these promising results, a placebo-controlled phase 2 “proof-of-concept” study is currently conducted in a number of leading European spinal cord injury centers.

For details on the clinical phase I study please consider the following website:

"ScienceSuisse" television programme featuring Martin Schwab (in German)

Click on the "SF Videoportal" link: SF Videoportal

"ScienceSuisse" television programme featuring Martin Schwab (in English)

See the following video: