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Institute for Regenerative Medicine • IREM

Thesis Defenses

Thesis defense talks are held by Ph.D. candidates after having submitted their thesis. The talk is public, given in English and will last about 45 minutes. It is followed by an oral exam in the presence of the 3 examiners and the candidate alone. The audience is thus asked to leave the lecture hall after the talk.

Thesis Defense Schedule 2024

Date Time Room Speaker Title

16th April 2024

9pm ETH Center, Leonhardstrasse 21, 8092 Zurich Dario Bachmann Risk and Protective Factors in the Development of Alzheimer's Disease

3rd June 2024

1pm WAD P106 Martina Nubiè Development of gene therapy for granulin-related neurodegeneration

17th June 2024

1pm WAD P106 Eric Gähwiler Combining Genome and Tissue Engineering for Next-Generation Human Biomimetics


Completed Doctoral Dissertations 2023

Dr. sc. nat. Kah Mun Siow
Development of a CRISPR-Based Knock-In Gene Therapy Strategy for p47phox-Deficient Chronic Granulomatous Disease

Dr. sc. nat. Nikolaos Poulis
Multiscale Characterization and Immunocompatibility Assessment of Human Tissue Engineered Matrices for Next Generation Heart Valve Applications

Dr. sc. nat. Polina Zaytseva
Development, Characterization and Validation of Xenogeneic Serum-Free Tissue Engineered Matrices for Cardiovascular Applications

Dr. sc. nat. Huimin Shan
Nogo-A inhibition combined with neurorehabilitation - A novel regenerative therapy for traumatic brain injury

Dr. sc. nat. Chiara Rickenbach
Immunophenotyping and Functional Analysis of Alzheimer’s Disease-Related T cells

Dr. sc. nat. Rebecca Weber
Stem Cell Therapy for Stroke

Dr. sc. nat. Myriam Scheuber
Effects of Neuromodulation and Training on the Recovery after Spinal Cord Injury

Completed Doctoral Dissertations 2022

Dr. sc. nat. Priyanka Ravikumar
Title: Development of Blood-Based Assays for Early Detection of Aβ42 Biomarker in Alzheimer’s Disease

Completed Doctoral Dissertations 2021

Dr. sc. nat. Marie Rouault
Title:Targeting the factor XII-driven contact system in Alzheimer’s disease-related pathology

Dr. sc. nat. Daphne Correa
Title: Antibody based therapeutic approaches for Neurodegenerative diseases

Dr. sc. nat. Sherida De Leeuw
Title: Investigating Fundamental Pathomechanisms in Alzheimer’s Disease Using Induced Pluripotent Stem Cell-Derived Neural Cells

Completed Doctoral Dissertations 2020

Dr. sc. nat. Andrea Sartori
Title: Neurogenic lower urinary tract dysfunction in severe spinal cord injured rats

Dr. sc. nat. Tunahan Kirabali
Title: Early Biomarkers of Impaired Beta-Amyloid Clearance

Completed Doctoral Dissertations 2019

Dr. sc. ETH Ruslan Rust
Title: Vascular repair and regeneration after ischemia

Dr. sc. nat. Mareike Göranson
Title: A ph-sensitive polyreactive human derived monoclonal antibody for selective tumor targeting

Dr. sc. nat. Mrityunjoy Mondal

Completed Doctoral Dissertations 2018

Dr. sc. nat. Kevin Meyer
Title: Human antibodies for targeting DPR proteins in C9orf72 ALS an FTD

Dr. sc. nat. Frances-Catherine Quevenco
Title: Funtional connectivity signatures of preclinical Alzheimer’s disease

Dr. sc. nat. Christoph Gericke
Title: The effect of beta-amyloid pathology on immune surveillance in the brain and peripheral blood

Dr. sc. nat. Christophe Chantre
Title: Engineering biomimetics instructive materials for wound healing and regeneration

Dr. sc. nat. Valentina Lintas
Off-the-shelf transcatheter tissue engineered heart valves: transition from pulmonary to aortic valve replacement

Dr. sc. nat. Anna Mallone
Title: Tissue Engineered Constructs to Model Early and Late-Stage Atherosclerosis

Dr. sc. nat. Vinod Udayar
Title: Membrane trafficking pathways in the production and clearance of the Alzheimer's disease Aβ  peptide in neurons and in microglia

Dr. sc. nat. Sarah Motta
Title: Transcatheter Off-the-shelf Tissue Engineered Heart Valve: Optimization of Valve Design Toward a Favorable Host Cell Response

Dr. sc. nat. Sabine Probst
Title: APP nuclear signaling and transcriptional regulation is mediated by Fe65 and Tip60

Completed Doctoral Dissertations 2017

Dr. sc. nat. Debora Kehl
Titel: Characterization of Mesenchymal Stem Cells for their Use in Cardiovascular Regenerative Medicine

Dr. sc. nat. Julian Hermann Birnbaum
Title: Modeling Sporadic Alzheimer’s Disease with Induced Pluripotent Stem Cells and Mechanisms of Aβ-Induced Synaptic Toxicity

Dr. sc. nat. Jiri Marinus Gerardus van Bergen
Title: MRI-PET for Investigating Cerebral Iron-Load and Associated Pathology in Preclinical Alzheimer’s Disease

Completed Doctoral Dissertations 2016

Dr. sc. nat. Sonja Grinschgl
Title: Regulation of NMDA Receptor Subunit Composition and Synaptic Alterations by the APP Intracellular Domain (AICD) in Hippocampal Neurons

Dr. sc. nat. Rebecca Derungs
Title: The role of the adaptor protein p66Shc in Alzheimer's disease-related pathology and cognitive dysfunction

Completed Doctoral Dissertations 2015

Dr. phil. Andrea Maria Kälin
Title: Evaluation of a cognitive and a morphometric marker for the early detection of Alzheimer’s disease

Dr. sc. nat. Fabian Wirth
Title: Therapeutic approaches in animal models of human protein misfolding diseases

Dr. sc. nat. Manuel Tobias Gersbacher
Title: Proteasomal degradation of the APP intracellular domain (AICD) and regulation of its nuclear signaling

Dr. sc. nat. Garima Thakur
Title: α-Synuclein – unconventional secretion and homeostatic regulation

Dr. sc. nat. Claudia Späni
Title: Role of the adaptive immune system in the pathogenesis of Alzheimer’s disease

Dr. med. Helena Elsa Hermann
Title: Decision-making capacity: the enigmatic gatekeeper for patients’ right to self-determination