This SNF project was initiated by Prof Ruth Tuura from the children’s hospital with whom we have a longstanding collaboration. We aim with this project to assess clearance mechanisms during sleep. We are focusing on the paravascular pathways for clearance of toxins and waste products in the brain. The so called glymphatic system will be assessed in our cohort participants with MRI sequences and we will use the SleepLoop system (HMZ Flagship product) to improve sleep and measure effects on the glymphatic system. Knowing the mechanisms and potential improvement of waste management in the brain could help to assess protective measures to prevent or reduce pathology accumulation and maintain a healthy balance.