Refueling the ischemic CNS: Guidance molecules for vascular repair
Patients suffering from ischemic strokes have limited therapeutic options and are often left with considerable disabilities. In order to promote neurological recovery, angiogenesis (the formation of new blood vessels) has been proposed as a promising therapeutic target. Apart from the most intensively studied angiogenic growth factors, recent research found that the process of vascular sprouting and migration also requires the participation of guidance molecules, many of which were initially identified as regulators of axonal growth. Here, Rust et al. review the inhibitory and growth promoting effects of guidance molecules on the vascular system and discuss their potential as novel angiogenic targets for neurovascular diseases.
The full article, published at https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(19)30087-6 was written by Ruslan Rust as part of his PhD project with the contribution of Lisa Grönnert, Rebecca Z. Weber, Geertje Mulders and Martin E. Schwab.