Rust et al: Anti-Nogo-A antibodies prevent vascular leakage and act as pro-angiogenic factors following stroke.

In this study, we demonstrate that antibody-mediated Nogo-A neutralization following stroke has strong pro-angiogenic effects but does not increase vascular permeability as opposed to the Vascular Endothelial Growth Factor (VEGF). Moreover, VEGF-induced vascular permeability was partially prevented when VEGF was co-administered with anti-Nogo-A antibodies. This study may provide a novel therapeutic strategy for vascular repair and maturation in the ischemic brain.

Benedikt Hochstrasser

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